Hormonal
Treatment with PPAR-gamma agonists (thiazolidinediones) increases circulating adiponectin levels, which may mediate their insulin-sensitizing effects.
Thiazolidinediones, a class of diabetes medications, work in part by increasing levels of the hormone adiponectin. This increase in adiponectin helps improve insulin sensitivity. If you are considering medication for diabetes, discuss with your doctor how these drugs might affect your hormonal balance and metabolic health.
The treatment with PPAR-gamma receptor agonists, thiazolidine-diones, increased circulating adiponectin levels under both experimental conditions in rodent models of obesity (Combs et al. 2002) and in patients with obesity/type 2 diabetes (Maeda et al. 2001), while metformin or PPAR-alpha agonists had no effect. It thus seems that part of the insulin-sensitizing effect of thiazolidinediones might be mediated by an increase of adiponectin levels.
Why this rating
Supported by studies in both rodent models and human patients with obesity/type 2 diabetes.
Source
Adiponectin and its role in the obesity-induced insulin resistance and related complications.
Martin Haluzı́k et al. · Physiological Research · 2004
DOI 10.33549/physiolres.930479
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