Hormonal
Obesity is associated with decreased plasma adiponectin levels, which correlates with insulin resistance and an increased risk of type 2 diabetes.
Research shows that people with obesity often have lower levels of adiponectin, a hormone that helps regulate insulin sensitivity. This hormonal imbalance contributes to insulin resistance and increases the risk of type 2 diabetes. Understanding this biological link can help reduce self-blame and highlight the importance of addressing metabolic health through lifestyle changes and medical support.
A number of clinical studies showed a decrease of adiponectin levels in obese humans relative to lean subjects... Adiponectin levels were also significantly higher in females relative to the males. Negative correlation between plasma adiponectin levels and body mass index or body fat was further supported by studies of Weyer et al.
Why this rating
Consistent findings across multiple clinical studies in different populations (Japanese, Caucasian, Pima Indian).
Source
Adiponectin and its role in the obesity-induced insulin resistance and related complications.
Martin Haluzı́k et al. · Physiological Research · 2004
DOI 10.33549/physiolres.930479
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