Research
Mixed
Accumulation of senescent endothelial cells and vascular smooth muscle cells drives the progression of atherosclerosis and hypertension.
Cellular aging in blood vessels contributes to heart disease and high blood pressure. Managing cardiovascular risk factors may help slow this process.
GoodSupportsHIGH confidence
Senescent endothelial cells and vascular smooth muscle cells are found in atherosclerotic plaque, and studies indicate that these cells are involved in progression of plaque.
Why this rating
Consistent evidence from human autopsy studies and animal models.
Source
Vascular Senescence in Cardiovascular and Metabolic Diseases
Goro Katsuumi et al. · Frontiers in Cardiovascular Medicine · 2018
DOI 10.3389/fcvm.2018.00018
narrative_reviewCited 192×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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