Research
Micronutrients & recovery
Higher circulating levels of long-chain omega-3 PUFAs are associated with a lower risk of worsening white matter grade over a 5-year period in older adults.
Consistent intake of long-chain omega-3s may help slow the progression of white matter changes in the brain, which are linked to cognitive decline. This benefit was observed in a 5-year follow-up, suggesting long-term consistency is key.
GoodSupportsHIGH confidence
In multivariable-adjusted analyses, participants in the highest EPA+DPA+DHA quartile had 42% lower odds of developing worsening white matter (OR, 0.58; 95% CI, 0.40 to 0.84; P for trend=0.002) compared with the lowest quartile.
Why this rating
Longitudinal design with serial MRIs strengthens the finding, though observational nature remains.
Source
Circulating Omega‐3 Polyunsaturated Fatty Acids and Subclinical Brain Abnormalities on MRI in Older Adults: The Cardiovascular Health Study
Jyrki K. Virtanen et al. · Journal of the American Heart Association · 2013
cohort · n=3660Cited 84×
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