Mixed
Higher abundance of bacterial L-methionine biosynthesis pathways is associated with increased presence of carotid plaque and maximum stenosis (atherosclerosis) in obese individuals.
In obese individuals, specific gut bacteria that produce L-methionine are linked to higher atherosclerosis risk. While this study is observational, it suggests that managing gut microbiome composition (potentially through diet) may be relevant to cardiovascular health, particularly in those with obesity. Focus on fiber-rich diets that support diverse microbiota.
higher abundance of bacterial L-methionine biosynthesis (HSERMETANAPWY) was significantly associated with the presence of plaque (P=0.001) and maximum stenosis (P=0.001)... in 300-OB cohort
Why this rating
Large cohort (n=297 obese) with deep phenotyping, rigorous statistical correction (FDR, permutation), and replication of association after adjusting for TMAO.
Source
Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk
Alexander Kurilshikov et al. · Circulation Research · 2019
DOI 10.1161/circresaha.118.314642
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