Mixed
Plasma levels of short-chain fatty acids (SCFAs), specifically acetate, are associated with lower cardiovascular disease (CVD) metabolic risk scores, whereas stool levels are not.
For cardiovascular health, the amount of short-chain fatty acids (like acetate) in your blood matters more than what's in your stool. Eating fiber-rich foods (fruits, vegetables, nuts) boosts these beneficial blood levels, which are linked to lower CVD risk. Focus on dietary patterns that support this absorption.
plasma level of acetate was associated to lower MRS (Beta=-0.09, P=7.2 x10-4)... no significant associations were found between stool levels of SCFAs and MRS
Why this rating
Large population cohort (n=978), rigorous statistical analysis, clear distinction between plasma and stool relevance.
Source
Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk
Alexander Kurilshikov et al. · Circulation Research · 2019
DOI 10.1161/circresaha.118.314642
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