Micronutrients & recovery
Single oral administration of Nicotinamide Mononucleotide (NMN) up to 500 mg is safe and well-tolerated in healthy men, causing no significant adverse clinical symptoms or changes in vital signs.
If you are a healthy man between 40 and 60, taking a single dose of NMN (up to 500mg) appears safe in the short term, with no observed negative effects on vital signs, liver enzymes, or general well-being. This does not prove long-term benefits, but it suggests the supplement is well-tolerated at these doses.
The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature... The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects.
Why this rating
Small sample size (n=10), single-arm design, lack of placebo control, and short duration (single dose).
Source
Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men
Junichiro Irie et al. · Endocrine Journal · 2019
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