Research
Micronutrients & recovery
Oral administration of NMN (100-500 mg) leads to a dose-dependent increase in plasma levels of its metabolites, specifically N-methyl-2-pyridone-5-carboxamide (2Py) and N-methyl-4-pyridone-5-carboxamide (4Py), indicating successful metabolic conversion.
Taking NMN orally results in measurable levels of its metabolites in your blood, suggesting your body absorbs and processes it. Higher doses (500mg) produce more of these metabolites than lower doses (100mg).
ModerateSupportsMEDIUM confidence
Plasma concentrations of N-methyl-2-pyridone-5-carboxamide and N-methyl-4-pyridone-5-carboxamide were significantly increased dose-dependently by NMN administration.
Why this rating
Small sample size, single dose, lack of tissue NAD+ measurement, and failure to detect NMN itself in plasma.
Source
Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men
Junichiro Irie et al. · Endocrine Journal · 2019
DOI 10.1507/endocrj.ej19-0313
clinical_trial · n=10Cited 189×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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