Research
Energy balance
Dietary restriction (DR) extends lifespan by triggering mitochondrial adaptations, including increased sirtuin activity and mitochondrial biogenesis via PGC-1α.
Consider dietary restriction as a primary strategy for longevity. It works by activating sirtuins and boosting mitochondrial biogenesis (via PGC-1α). While the exact dose isn't defined here, the mechanism suggests that reducing caloric intake triggers protective mitochondrial adaptations.
GoodSupportsHIGH confidence
Dietary restriction (DR) is the most widely used intervention to extend lifespan... It is well established that mitochondria are major contributors to the cellular adaptations needed to prolong lifespan during DR... Several mechanisms have been proposed to underlie the increase in lifespan by DR, an increase in the deacetylase activity of sirtuins and an augmentation of mitochondrial biogenesis being two of them.
Why this rating
Cites well-established consensus and specific studies on yeast mutants and sirtuin activation.
Source
Mitochondria and Ageing
Christiaan Leeuwenburgh et al. · Journal of Aging Research · 2011
DOI 10.4061/2011/782946
narrative_reviewCited 188×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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