Mixed
Variations in gut microbiota composition affect the absorption, distribution, metabolism, and excretion (ADME) of environmental chemicals, thereby altering individual exposure to obesogenic and diabetogenic toxins.
While you cannot easily control environmental chemical exposure, understanding that your gut health influences how your body processes these chemicals highlights the importance of maintaining a diverse microbiome. This may mitigate the internal impact of unavoidable environmental toxins, though more human research is needed to confirm specific interventions.
The toxicology and pharmacology literature also suggests that interindividual variations in gut micro biota may affect chemical metabolism via direct activation of chemicals, depletion of metabolites needed for biotransformation, alteration of host biotransformation enzyme activities, changes in enterohepatic circulation, altered bioavailability of environmental chemicals and/or antioxidants from food, and alterations in gut motility and barrier function.
Why this rating
The paper is a review citing multiple animal and in vitro studies, but notes a lack of human studies specifically linking microbiome variations to the ADME of obesogens.
Source
Do Interactions Between Gut Ecology and Environmental Chemicals Contribute to Obesity and Diabetes?
Suzanne M. Snedeker et al. · Environmental Health Perspectives · 2011
DOI 10.1289/ehp.1104204
More from this paper
- Gut microbiota composition influences obesity and diabetes risk through mechanisms including energy harvesting, regulation of fat storage, and induction of metabolic endotoxemia.Good
- Certain environmental chemicals (obesogens and diabetogens) can disrupt metabolic homeostasis by acting on nuclear receptors involved in adipogenesis and insulin sensitivity.Moderate
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