Energy balance
Gut microbiota composition influences obesity and diabetes risk through mechanisms including energy harvesting, regulation of fat storage, and induction of metabolic endotoxemia.
Maintaining a diverse gut microbiome through diet may help regulate energy extraction and satiety hormones. While not a substitute for healthy eating, a healthy microbiome may support metabolic health and reduce inflammation associated with obesity.
In addition to their role in energy harvesting in the gut, micro biota may also affect obesity and diabetes risk via several other mechanisms including regulation of fat storage... metabolic endotoxemia-induced inflammation... and levels of satiety factors.
Why this rating
Supported by multiple animal studies (germ-free, ob/ob mice) and human observational studies, though human causality is still being established.
Source
Do Interactions Between Gut Ecology and Environmental Chemicals Contribute to Obesity and Diabetes?
Suzanne M. Snedeker et al. · Environmental Health Perspectives · 2011
DOI 10.1289/ehp.1104204
More from this paper
- Variations in gut microbiota composition affect the absorption, distribution, metabolism, and excretion (ADME) of environmental chemicals, thereby altering individual exposure to obesogenic and diabetogenic toxins.Moderate
- Certain environmental chemicals (obesogens and diabetogens) can disrupt metabolic homeostasis by acting on nuclear receptors involved in adipogenesis and insulin sensitivity.Moderate
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