Research
Mixed
Mitochondrial dysfunction and elevated ROS production drive lipid peroxidation, which contributes to biological aging and age-related diseases.
Focus on maintaining mitochondrial health through lifestyle factors that support energy metabolism and reduce oxidative stress, as these are key drivers of aging and age-related diseases.
GoodSupportsHIGH confidence
Disruption of lipid homeostasis can promote pathological changes that contribute towards biological ageing and age-related diseases. Several age-related diseases have been associated with altered lipid metabolism and an elevation in highly damaging lipid peroxidation products; the latter has been ascribed, at least in part, to mitochondrial dysfunction and elevated ROS formation.
Why this rating
Review article citing multiple studies, but not a primary clinical trial.
Source
Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
Opeyemi Stella Ademowo et al. · Biogerontology · 2017
DOI 10.1007/s10522-017-9710-z
narrative_reviewCited 181×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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