Research
Mixed
Oxidized phospholipids (oxPLs) can have protective effects, including inhibition of inflammatory signaling and upregulation of antioxidant genes, under certain biological conditions.
Understand that not all oxidation products are harmful; some, like oxPLs, may have protective roles in specific contexts.
ModerateQualifiesMEDIUM confidence
Mauerhofer et al. have demonstrated that OxPLs can also induce protective effects such as inhibition of inflammatory signaling pathways through Nrf2-dependent and -independent mechanisms, upregulation of antioxidant genes, antagonism of Toll-like receptors.
Why this rating
Cites specific studies (Mauerhofer et al., Bochkov et al.) but within a review context.
Source
Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
Opeyemi Stella Ademowo et al. · Biogerontology · 2017
DOI 10.1007/s10522-017-9710-z
narrative_reviewCited 181×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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