Energy balance
A 24-hour fast blunts NLRP3 inflammasome activation in human subjects by activating SIRT3, which enhances mitochondrial integrity and reduces ROS, whereas refeeding primes the inflammasome via NF-κB signaling.
A 24-hour fast reduces markers of sterile inflammation (NLRP3) in healthy people by activating a specific protein (SIRT3) that protects mitochondria. If you are healthy, a single day of fasting may have anti-inflammatory benefits compared to eating normally, provided you do not have underlying conditions that contraindicate fasting.
Together, our data indicate that nutrient levels regulate the NLRP3 inflammasome, in part through SIRT3-mediated mitochondrial homeostatic control.
Why this rating
Human clinical trial with mechanistic depth (SIRT3, ROS, cytokines), but small sample size (n=19) and short duration (24h).
Source
Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects
Javier Traba et al. · Journal of Clinical Investigation · 2015
DOI 10.1172/jci83260
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