Research
Micronutrients & recovery
Nicotinamide Riboside (NR), a SIRT3 agonist, blunts NLRP3 inflammasome activation and improves mitochondrial function in leukocytes from refed (fed) subjects, mimicking the effects of fasting.
Taking Nicotinamide Riboside (NR) for 24 hours can reduce inflammation markers in blood cells, mimicking the effects of a 24-hour fast. This suggests NR may be a useful tool for managing inflammation without requiring prolonged fasting.
GoodSupportsHIGH confidence
The 24-hour administration of NR to PBMCs from healthy volunteers mimicked the fasting effect with blunting of inflammasome activation
Why this rating
Human cells (ex vivo) and healthy volunteers, but no long-term clinical outcomes or dosing optimization data.
Source
Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects
Javier Traba et al. · Journal of Clinical Investigation · 2015
crossover · n=19Cited 180×
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