Hormonal
Therapeutic silencing of miR-33 using antisense oligonucleotides increases plasma HDL cholesterol levels by targeting cholesterol efflux transporters ABCA1 and ABCG1.
While direct 'miR-33 silencing' is not a current consumer supplement, this research highlights why some individuals struggle with HDL levels despite diet. Future therapies targeting this pathway may offer treatment for dyslipidemia, but current lifestyle interventions (diet/exercise) remain the primary method to influence these genetic pathways naturally.
Silencing of miR-33 in vivo increased plasma HDL levels by targeting adenosine triphosphate-binding cassette transporter A1 (ABCA1) and adenosine triphosphate-binding cassette transporter G1 (ABCG1), thereby attenuating cholesterol efflux to apolipoprotein A1 (ApoA1) or reducing cholesterol efflux to nascent HDL.
Why this rating
The paper is a review summarizing multiple studies (in vivo mouse models, non-human primates), but does not present a single primary clinical trial itself.
Source
Emerging role of microRNAs in lipid metabolism
Zhihong Yang et al. · Acta Pharmaceutica Sinica B · 2015
DOI 10.1016/j.apsb.2015.01.002
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