Research
Hormonal
Overexpression of miR-27a accelerates adipolysis (fat breakdown) by targeting RXRα and PPARγ, thereby reducing lipid storage in cells.
miR-27a promotes fat breakdown. While not a current supplement, understanding this pathway may lead to future treatments for obesity that target fat storage genes.
ModerateSupportsMEDIUM confidence
Overexpression of miR-27a accelerates adipolysis by releasing more glycerol and free fatty acids in the adipocytes and represses lipid storage in cells.
Why this rating
Review paper citing multiple in vitro and in vivo studies.
Source
Emerging role of microRNAs in lipid metabolism
Zhihong Yang et al. · Acta Pharmaceutica Sinica B · 2015
DOI 10.1016/j.apsb.2015.01.002
narrative_reviewCited 173×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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