Research
Hormonal
Inhibition of miR-122 using antisense therapy significantly reduces circulating cholesterol and triglyceride levels in the liver.
Anti-miR-122 therapy is a potential future treatment for fatty liver and high cholesterol. It works by blocking a specific liver RNA (miR-122) that normally promotes cholesterol production. Current management relies on diet and exercise, but this pathway may soon be targetable by drugs.
ModerateSupportsMEDIUM confidence
Anti-miR-122 therapy resulted in a significant reduction (25%–30%) of circulating cholesterol levels.
Why this rating
Review paper citing multiple in vivo studies.
Source
Emerging role of microRNAs in lipid metabolism
Zhihong Yang et al. · Acta Pharmaceutica Sinica B · 2015
DOI 10.1016/j.apsb.2015.01.002
narrative_reviewCited 173×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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