Research
Mixed
Isocaloric substitution of fructose for other carbohydrates significantly decreases diastolic and mean arterial blood pressure.
Substituting fructose for other carbohydrates at the same calorie level may slightly lower diastolic and mean arterial blood pressure.
GoodSupportsMEDIUM confidence
Overall, fructose intake in isocaloric exchange for other carbohydrates significantly decreased diastolic (mean difference: -1.54 [95% CI: -2.77 to -0.32]) and mean arterial pressure (mean difference: -1.16 [95% CI: -2.15 to -0.18]).
Why this rating
Meta-analysis of 15 controlled feeding trials.
Source
Effect of Fructose on Blood Pressure
Vanessa Ha et al. · Hypertension · 2012
DOI 10.1161/hypertensionaha.111.182311
Meta-analysis · 15 studiesCited 172×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Isocaloric substitution of fructose for other carbohydrates does not adversely affect blood pressure in humans, specifically showing no significant effect on systolic blood pressure.Good
- Hypercaloric fructose feeding does not significantly affect mean arterial blood pressure compared to other carbohydrates.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →