Hormonal
Age-related decline in α-Klotho expression in muscle progenitor cells drives mitochondrial dysfunction and impaired muscle regeneration.
Maintaining or boosting α-Klotho levels may support muscle repair as you age. While direct supplementation isn't a standard consumer product yet, understanding this pathway highlights the importance of factors that support mitochondrial health and hormonal balance in aging.
These studies identify a role for α-Klotho in the regulation of MPC mitochondrial function and implicate α-Klotho declines as a driver of impaired muscle regeneration with age.
Why this rating
Strong mechanistic evidence in mice with genetic and pharmacological interventions, but human data is limited to observational correlations.
Source
Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
Amrita Sahu et al. · Nature Communications · 2018
DOI 10.1038/s41467-018-07253-3
More from this paper
- Supplementation with exogenous α-Klotho restores mitochondrial DNA integrity and bioenergetics in aged muscle progenitor cells, enhancing functional regeneration.Good
- Restoration of mitochondrial ultrastructure via SS-31 peptide treatment rescues the regenerative defects caused by α-Klotho deficiency.Good
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