Research
Hormonal
Supplementation with exogenous α-Klotho restores mitochondrial DNA integrity and bioenergetics in aged muscle progenitor cells, enhancing functional regeneration.
Exogenous α-Klotho supplementation shows promise in restoring muscle regeneration in aged models by fixing mitochondrial function. This suggests potential future therapies for age-related muscle loss.
GoodSupportsHIGH confidence
Conversely, supplementation with α-Klotho restored mtDNA integrity and bioenergetics of aged MPCs to youthful levels in vitro and enhanced functional regeneration of aged muscle in vivo in a temporally-dependent manner.
Why this rating
Strong evidence in animal models showing reversal of phenotype.
Source
Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
Amrita Sahu et al. · Nature Communications · 2018
DOI 10.1038/s41467-018-07253-3
mechanism_onlyCited 170×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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