Research
Energy balance
Restoration of mitochondrial ultrastructure via SS-31 peptide treatment rescues the regenerative defects caused by α-Klotho deficiency.
Targeting mitochondrial health with peptides like SS-31 may help overcome regeneration deficits in individuals with low α-Klotho levels.
GoodSupportsHIGH confidence
the regenerative defect of Kl+/− mice is rescued at the cellular and organismal level when mitochondrial ultrastructure is restored through treatment with the mitochondria-targeted peptide, SS-31
Why this rating
Strong mechanistic evidence in animal models.
Source
Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
Amrita Sahu et al. · Nature Communications · 2018
DOI 10.1038/s41467-018-07253-3
mechanism_onlyCited 170×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Age-related decline in α-Klotho expression in muscle progenitor cells drives mitochondrial dysfunction and impaired muscle regeneration.Good
- Supplementation with exogenous α-Klotho restores mitochondrial DNA integrity and bioenergetics in aged muscle progenitor cells, enhancing functional regeneration.Good
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →