Hormonal
Insulin resistance in the skeletal muscle vasculature impairs capillary recruitment and nitric oxide bioavailability, which directly limits insulin-stimulated glucose uptake.
If you have insulin resistance, simply exercising may not be enough if your blood vessels aren't delivering insulin to your muscle cells effectively. Focus on strategies that improve vascular health, such as weight loss and specific medications, alongside physical activity, to ensure insulin can reach the muscle to process glucose.
IR in the skeletal muscle vasculature results in impaired skeletal muscle glucose uptake and altered whole-body glucose homeostasis.
Why this rating
The paper is a review citing multiple human and animal studies, including clamp techniques and imaging, though it does not present new primary data.
Source
Insulin Resistance and Skeletal Muscle Vasculature: Significance, Assessment and Therapeutic Modulators
Camila Manrique et al. · Cardiorenal Medicine · 2014
DOI 10.1159/000368423
More from this paper
- Lifestyle interventions, specifically weight loss and regular physical activity, improve endothelial function and insulin sensitivity in the skeletal muscle vasculature.Good
- High-fructose corn syrup intake impairs insulin response in the skeletal muscle vasculature and contributes to insulin resistance.Moderate
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