Research
Mixed
High-fructose corn syrup intake impairs insulin response in the skeletal muscle vasculature and contributes to insulin resistance.
Reduce intake of high-fructose corn syrup found in processed foods and sugary drinks. While clinical trials are still clarifying the exact cardiovascular risk, evidence suggests that high fructose intake directly impairs how your blood vessels respond to insulin.
ModerateRefutesMEDIUM confidence
Systemic and vascular IR have not only been related to overnutrition, but also specifically to an increased intake of high-fructose corn syrup.
Why this rating
Cites observational and mechanistic studies, but notes clinical trials are needed for specific cardiovascular risk clarification.
Source
Insulin Resistance and Skeletal Muscle Vasculature: Significance, Assessment and Therapeutic Modulators
Camila Manrique et al. · Cardiorenal Medicine · 2014
DOI 10.1159/000368423
narrative_reviewCited 20×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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