Research
Adherence
Lifestyle interventions, specifically weight loss and regular physical activity, improve endothelial function and insulin sensitivity in the skeletal muscle vasculature.
To fix insulin resistance, combine moderate exercise (150 minutes/week) with a modest calorie deficit (500 calories/day) for at least 6 months. This specific combination has been shown to physically improve how your blood vessels deliver insulin to your muscles.
GoodSupportsHIGH confidence
In subjects with DM2, weight loss and regular physical activity are known to positively modify metabolic abnormalities that are correlated with vascular disease.
Why this rating
Cites large trials like Look AHEAD and multiple smaller studies showing consistent improvements.
Source
Insulin Resistance and Skeletal Muscle Vasculature: Significance, Assessment and Therapeutic Modulators
Camila Manrique et al. · Cardiorenal Medicine · 2014
narrative_reviewCited 20×
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