Research
Micronutrients & recovery
Dysbiotic gut microbiota and its derived metabolites (such as TMAO, choline, and hippurate) are shared metabolic biomarkers across cardiometabolic diseases, contributing to inflammation, atherosclerosis, and insulin resistance.
Support gut health through a diverse, fiber-rich diet to potentially lower levels of harmful metabolites like TMAO, which are linked to cardiovascular risk and insulin resistance.
GoodSupportsHIGH confidence
Dysbiotic gut microbiota metabolites such as trimethyl-amine-oxide (TMAO), choline, and hippurate are also linked to obesity... TMAO has been found to be associated with major cardiovascular events and mortality risk in T2DM.
Why this rating
Supported by multiple metabolomic studies cited in the review.
Source
The metabolic signatures of cardiometabolic diseases: Does the shared metabotype offer new therapeutic targets?
Arwa M. Amin · Lifestyle Medicine · 2021
DOI 10.1002/lim2.25
narrative_reviewCited 17×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Insulin resistance (IR) and the resulting hyperinsulinemia constitute the primary shared pathogenic mechanism linking metabolic syndrome, obesity, and type 2 diabetes (T2DM), driving cardiovascular disease (CVD) risk through prothrombotic effects, endothelial dysfunction, and atherogenic dyslipidemia.Good
- Metabolomic profiling (metabotyping) reveals that metabolic syndrome, obesity, T2DM, and CVDs share common metabolic signatures and pathways, suggesting that dietary interventions and pharmacologic treatments can target these shared traits.Good
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