Hormonal
The magnitude of the acute satellite cell (SC) response to resistance exercise, specifically the expansion of type I fiber-associated SC between 24 and 72 hours post-exercise, positively correlates with the degree of skeletal muscle hypertrophy achieved following long-term resistance training.
If you want to maximize muscle growth from resistance training, focus on exercises that trigger a strong satellite cell response. This study suggests that the ability of your body to expand the satellite cell pool associated with type I muscle fibers in the 24-72 hours after a workout is a key predictor of how much muscle you will gain over time. This implies that recovery and the cellular environment post-workout are just as important as the workout intensity itself.
examination of individual responses revealed a significant correlation between the relative changes in SC associated with type I fibres between 24 and 72 hours following acute exercise completed before the onset of training and the relative change in quadriceps volume as assessed by MRI following 16 weeks of training (r2 = 0.566; p = 0.012)
Why this rating
Randomized controlled trial with a relatively large sample size for this type of mechanistic study (n=23), using gold-standard MRI for hypertrophy measurement and rigorous immunofluorescence for SC quantification.
Source
The Acute Satellite Cell Response and Skeletal Muscle Hypertrophy following Resistance Training
Leeann M. Bellamy et al. · PLoS ONE · 2014
DOI 10.1371/journal.pone.0109739
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- The expansion of the satellite cell pool associated with type II muscle fibers following long-term resistance training correlates with the degree of skeletal muscle hypertrophy.Good
- Myostatin (MSTN) co-localization with satellite cells decreases acutely following resistance exercise but returns to baseline levels after long-term resistance training, suggesting MSTN regulation occurs at the whole muscle level rather than specifically at the satellite cell level during chronic adaptation.Good
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