Research
Hormonal
The expansion of the satellite cell pool associated with type II muscle fibers following long-term resistance training correlates with the degree of skeletal muscle hypertrophy.
Long-term resistance training leads to an expansion of the satellite cell pool, particularly in type II fibers, which is associated with greater muscle growth. This suggests that consistent training over weeks and months helps build a larger reservoir of stem cells, supporting larger muscle fibers.
GoodSupportsHIGH confidence
There was a correlation between the change in SC associated with type II fibres following training and the change in quadriceps volume (r2 = 0.49; p = 0.027)
Why this rating
Same high-quality RCT design as N1.
Source
The Acute Satellite Cell Response and Skeletal Muscle Hypertrophy following Resistance Training
Leeann M. Bellamy et al. · PLoS ONE · 2014
DOI 10.1371/journal.pone.0109739
rct · n=23Cited 150×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The magnitude of the acute satellite cell (SC) response to resistance exercise, specifically the expansion of type I fiber-associated SC between 24 and 72 hours post-exercise, positively correlates with the degree of skeletal muscle hypertrophy achieved following long-term resistance training.Good
- Myostatin (MSTN) co-localization with satellite cells decreases acutely following resistance exercise but returns to baseline levels after long-term resistance training, suggesting MSTN regulation occurs at the whole muscle level rather than specifically at the satellite cell level during chronic adaptation.Good
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