Hormonal
GLP-1 administration (25 nmol/kg) significantly augments glucose-stimulated insulin secretion and improves glucose tolerance in mice, whereas GLP-2 (25 nmol/kg) improves glucose tolerance without directly augmenting insulin secretion.
Both GLP-1 and GLP-2 peptides improve blood glucose levels in mice, but they do so through different biological pathways. GLP-1 works by telling beta cells to release more insulin, while GLP-2 improves glucose handling without directly increasing insulin secretion. This suggests that targeting GLP-2 receptors could be a viable strategy for glucose control that avoids potential side effects of excessive insulin secretion.
GLP-1, but not GLP-2, concentration dependently augmented insulin secretion... When injected conjointly with glucose, both peptides improved glucose disposal, which was associated with enhanced glucose-stimulated insulin secretion by GLP-1, but not GLP-2.
Why this rating
Robust in vivo and in vitro data in mice, but lacks human clinical trials.
Source
Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation
Asif Ali et al. · Biomolecules · 2024
DOI 10.3390/biom14121520
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