Research
Hormonal
Both GLP-1 and GLP-2 suppress appetite and reduce food intake in mice, regardless of their differential effects on insulin secretion.
Both GLP-1 and GLP-2 peptides reduce food intake in mice, suggesting that GLP-2 could be used to manage appetite without necessarily stimulating insulin secretion. This makes GLP-2 a potential candidate for obesity treatment where insulin secretion is not desired.
GoodSupportsHIGH confidence
In overnight fasted healthy mice, as well as mice trained to eat for 3 h per day, the administration of GLP-1 or GLP-2 suppressed appetite.
Why this rating
Consistent findings across two different mouse models (fasted and restricted feeding).
Source
Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation
Asif Ali et al. · Biomolecules · 2024
DOI 10.3390/biom14121520
mechanism_onlyCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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