Research
Hormonal
Both GLP-1 and GLP-2 promote beta-cell proliferation and protect against cytokine-induced apoptosis, preserving beta-cell mass and function.
Both GLP-1 and GLP-2 help protect beta-cells from death and promote their growth. This suggests that GLP-2 could be used to preserve beta-cell mass in diabetes, potentially slowing disease progression.
GoodSupportsHIGH confidence
Both GLP-1 and GLP-2 promoted beta-cell proliferation and protected against cytokine-induced apoptosis.
Why this rating
Strong in vitro data using established cell lines and staining techniques.
Source
Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation
Asif Ali et al. · Biomolecules · 2024
DOI 10.3390/biom14121520
mechanism_onlyCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- GLP-1 administration (25 nmol/kg) significantly augments glucose-stimulated insulin secretion and improves glucose tolerance in mice, whereas GLP-2 (25 nmol/kg) improves glucose tolerance without directly augmenting insulin secretion.Good
- Both GLP-1 and GLP-2 suppress appetite and reduce food intake in mice, regardless of their differential effects on insulin secretion.Good
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