Research
Macro partitioning
NuSH therapies induce significant weight loss that often includes loss of lean mass and skeletal muscle, creating a risk for sarcopenic obesity if body composition is not monitored.
Monitor your body composition, not just your weight. If you are on NuSHs, ensure your treatment plan includes resistance training and protein optimization to preserve muscle mass, as weight loss alone may hide muscle loss.
GoodSupportsHIGH confidence
Alongside the significant reduction in fat mass, individuals living with overweight and obesity receiving NuSHs may experience a reduction in lean mass, mainly through skeletal muscle loss.
Why this rating
Supported by multiple references (e.g., Ref 8, 21) and the review's finding that only 20.4% of trials measure body composition.
Source
Nutritional and functional outcomes in trials of nutrient‐stimulated hormone‐based therapy—A systematic mapping review
Sébastien Czernichow et al. · Obesity Reviews · 2025
systematic_reviewCited 9×
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