Research
Hormonal
Current NuSH trials rarely assess bone health, despite the known risk of bone mass reduction associated with significant weight loss.
If you are on NuSHs, ask your doctor about bone density scans, especially if you are post-menopausal or elderly. Ensure adequate calcium and vitamin D intake, as weight loss can compromise bone strength.
GoodRefutesHIGH confidence
Evaluations of bone health... were reported in less than 5% of the total trials each.
Why this rating
Based on systematic mapping data showing <5% reporting rate.
Source
Nutritional and functional outcomes in trials of nutrient‐stimulated hormone‐based therapy—A systematic mapping review
Sébastien Czernichow et al. · Obesity Reviews · 2025
DOI 10.1111/obr.13890
systematic_reviewCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Current randomized controlled trials of nutrient-stimulated hormone-based therapies (NuSHs) for obesity predominantly fail to assess nutritional and functional outcomes, focusing almost exclusively on body weight.Good
- NuSH therapies induce significant weight loss that often includes loss of lean mass and skeletal muscle, creating a risk for sarcopenic obesity if body composition is not monitored.Good
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