Research
Mixed
Current randomized controlled trials of nutrient-stimulated hormone-based therapies (NuSHs) for obesity predominantly fail to assess nutritional and functional outcomes, focusing almost exclusively on body weight.
If you are participating in or designing a NuSH trial, you must include nutritional and functional assessments (body composition, muscle strength, bone health) alongside weight. Relying solely on weight masks potential risks like sarcopenia and bone loss.
GoodRefutesHIGH confidence
The present review has shown the sparse reporting of nutritional and functional outcomes in RCTs evaluating the impact of NuSHs.
Why this rating
Based on a systematic mapping of 417 registered RCTs, providing high-level evidence of a systemic gap.
Source
Nutritional and functional outcomes in trials of nutrient‐stimulated hormone‐based therapy—A systematic mapping review
Sébastien Czernichow et al. · Obesity Reviews · 2025
DOI 10.1111/obr.13890
systematic_reviewCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- NuSH therapies induce significant weight loss that often includes loss of lean mass and skeletal muscle, creating a risk for sarcopenic obesity if body composition is not monitored.Good
- Current NuSH trials rarely assess bone health, despite the known risk of bone mass reduction associated with significant weight loss.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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