Research
Mixed
Pharmacological therapy should be discontinued if there is a lack of therapeutic response, defined as less than 5% weight loss after 12 weeks of optimal dosing, or if the patient experiences intolerance.
If you've been taking your weight-loss medication at the full dose for 12 weeks and haven't lost at least 5% of your body weight, talk to your doctor about stopping it. Continuing it is unlikely to be effective and may expose you to unnecessary side effects.
WeakRefutesHIGH confidence
Treatment may be discontinued under the following circumstances: lack of therapeutic response (<5% weight loss after 12 weeks with the optimal recommended dose); intolerance of active components; changes in clinical scenario; and women wanting to become pregnant or pregnant during therapy (R: I).
Why this rating
Class I recommendation.
Source
Consensus on pharmacological treatment of obesity in Latin America
Ana María Cappelletti et al. · Obesity Reviews · 2023
DOI 10.1111/obr.13683
clinical_guidelineCited 7×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Pharmacological treatment for obesity is indicated for adults with a BMI ≥30 kg/m², or ≥27 kg/m² with at least one comorbidity, when lifestyle changes are insufficient to achieve or maintain weight loss objectives.Weak
- Anti-obesity medications should be used as part of a multidisciplinary approach that includes lifestyle changes, behavioral management, and long-term follow-up, rather than as a standalone solution.Weak
Related findings · Mixed
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