Adherence
A remote, call-center-directed weight loss intervention combining diet and exercise counseling does not result in significant weight loss or improved cardiovascular risk factors in adult survivors of childhood acute lymphoblastic leukemia (ALL) compared to self-directed weight loss.
Standard remote weight loss programs are unlikely to succeed for adult survivors of childhood leukemia. Success requires tailoring to their specific health history, including managing pain and other treatment side effects, and likely involves more direct clinician involvement rather than purely remote coaching.
A remote weight-loss intervention that was successful among adults with CV conditions did not result in significant weight loss among adult survivors of childhood ALL.
Why this rating
Phase 3 randomized controlled trial, though with high attrition and low adherence limiting generalizability of the 'failure' to non-adherent populations.
Source
Exercise and QUality Diet after Leukemia: A Randomized Weight Loss Trial among Adult Survivors of Childhood Leukemia in the Childhood Cancer Survivor Study
Danielle Novetsky Friedman et al. · Cancer Epidemiology Biomarkers & Prevention · 2024
DOI 10.1158/1055-9965.epi-23-1601
More from this paper
- Among adherent participants (completing ≥80% of coaching calls), the same remote weight loss intervention resulted in significant weight loss compared to non-adherent participants.Good
- College-educated adult survivors of childhood ALL who adhered to the remote weight loss intervention experienced significant weight loss, whereas those with only high school education gained weight.Moderate
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
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