Adherence
A remote, call-center-directed weight loss intervention combining diet and exercise counseling does not result in significant weight loss or improved cardiovascular risk factors in adult survivors of childhood acute lymphoblastic leukemia (ALL) compared to self-directed weight loss.
Standard remote weight loss programs are unlikely to succeed for adult survivors of childhood leukemia. Success requires tailoring to their specific health history, including managing pain and other treatment side effects, and likely involves more direct clinician involvement rather than purely remote coaching.
A remote weight-loss intervention that was successful among adults with CV conditions did not result in significant weight loss among adult survivors of childhood ALL.
Why this rating
Phase 3 randomized controlled trial, though with high attrition and low adherence limiting generalizability of the 'failure' to non-adherent populations.
Source
Exercise and QUality Diet after Leukemia: A Randomized Weight Loss Trial among Adult Survivors of Childhood Leukemia in the Childhood Cancer Survivor Study
Danielle Novetsky Friedman et al. · Cancer Epidemiology Biomarkers & Prevention · 2024
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