Research
Adherence
Among adherent participants (completing ≥80% of coaching calls), the same remote weight loss intervention resulted in significant weight loss compared to non-adherent participants.
If you can commit to the full program, including regular check-ins, significant weight loss is possible. The key is adherence, which may require more support or tailored engagement strategies for cancer survivors.
GoodQualifiesMEDIUM confidence
The average difference in weight change from baseline to 24-months between participants in the intervention arm who were adherent (n=27) compared to those who were not (n=154) was −5.7 kg (95% CI, −9.35, −2.07)
Why this rating
Subgroup analysis of a phase 3 RCT; small sample size in the adherent subgroup (n=27).
Source
Exercise and QUality Diet after Leukemia: A Randomized Weight Loss Trial among Adult Survivors of Childhood Leukemia in the Childhood Cancer Survivor Study
Danielle Novetsky Friedman et al. · Cancer Epidemiology Biomarkers & Prevention · 2024
DOI 10.1158/1055-9965.epi-23-1601
rct · n=358Cited 5×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A remote, call-center-directed weight loss intervention combining diet and exercise counseling does not result in significant weight loss or improved cardiovascular risk factors in adult survivors of childhood acute lymphoblastic leukemia (ALL) compared to self-directed weight loss.Good
- College-educated adult survivors of childhood ALL who adhered to the remote weight loss intervention experienced significant weight loss, whereas those with only high school education gained weight.Moderate
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
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