Energy balance
In patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), achieving a baseline Body Mass Index (BMI) of 30 kg/m² or higher is a significant independent predictor of achieving clinically relevant weight loss (≥7% of initial body weight) through lifestyle interventions.
If you have MASLD and a BMI of 30 or higher, you are statistically more likely to achieve significant weight loss through lifestyle changes than someone with a lower BMI. This is likely due to higher energy expenditure at rest. Use this advantage by committing to the lifestyle changes early, as your body is primed to respond to caloric deficits more robustly than those with lower baseline weights.
Multiple adjusted regression analysis identified baseline BMI between 30 and 34.9 kg/m2 (odds ratio, OR = 1.95, 95% confidence interval, CI: 1.30–2.95) or ≥ 35 kg/m2 (OR = 2.08, 95% CI: 1.21–3.57)... as independent predictors of relevant weight loss.
Why this rating
Retrospective multicenter study with a large sample size (n=897) and adjusted for multiple confounders, though observational design limits causal inference.
Source
Key Predictors of Relevant Weight Loss in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease
Nicola Pugliese et al. · United European Gastroenterology Journal · 2025
DOI 10.1002/ueg2.70055
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