Energy balance
Sustained weight loss of at least 5% is recommended for individuals with overweight or obesity at moderate atherosclerotic cardiovascular disease (ASCVD) risk to reduce cardiometabolic risk factors and delay type 2 diabetes onset.
If you are at moderate cardiovascular risk, aim to lose just 5% of your body weight through a daily calorie deficit of 500-750 calories and 150 minutes of weekly exercise. This modest loss is scientifically proven to significantly lower your blood pressure, improve cholesterol, and drastically reduce your risk of developing type 2 diabetes.
Sustained weight reduction of at least 5% is RECOMMENDED in individuals with overweight or obesity at MODERATE ASCVD RISK to reduce CV risk factors, such as hypertension and dyslipidaemia, and to delay or prevent type 2 diabetes onset.
Why this rating
Based on multiple RCTs (DPP, Look AHEAD) and meta-analyses with low heterogeneity.
Source
2025 Brazilian evidence-based guideline on the management of obesity and prevention of cardiovascular disease and obesity-associated complications: a position statement by five medical societies
Cynthia Melissa Valério et al. · Diabetology & Metabolic Syndrome · 2025
DOI 10.1186/s13098-025-01954-8
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Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
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