Energy balance
Sustained weight loss of at least 10% from maximum weight is recommended for adults with overweight or obesity at moderate or high ASCVD risk to reduce cardiovascular events.
If you are at moderate or high cardiovascular risk, aim to lose 10% of your maximum lifetime weight. This is a higher bar than the 5% target for lower-risk individuals, but it is the threshold shown to significantly reduce the risk of heart attacks and strokes. Discuss with your doctor if pharmacotherapy (like GLP-1s) or surgery is appropriate to help you reach this target.
Sustained reduction of at least 10% from maximum weight SHOULD BE CONSIDERED in adults with overweight or obesity at MODERATE or HIGH ASCVD RISK to reduce CV events.
Why this rating
Based on RCTs (Da-Qing, Look AHEAD post-hoc) and observational data, though some evidence is from post-hoc analyses.
Source
2025 Brazilian evidence-based guideline on the management of obesity and prevention of cardiovascular disease and obesity-associated complications: a position statement by five medical societies
Cynthia Melissa Valério et al. · Diabetology & Metabolic Syndrome · 2025
DOI 10.1186/s13098-025-01954-8
More from this paper
- Sustained weight loss of at least 5% is recommended for individuals with overweight or obesity at moderate atherosclerotic cardiovascular disease (ASCVD) risk to reduce cardiometabolic risk factors and delay type 2 diabetes onset.Strong
- Treatment with GLP-1 receptor agonists (e.g., semaglutide 2.4 mg, liraglutide 3.0 mg) or GLP-1/GIP co-agonists (tirzepatide) is recommended for adults with overweight or obesity at moderate or high ASCVD risk to reduce weight and cardiovascular risk factors.Strong
- Semaglutide 2.4 mg is recommended for secondary prevention of cardiovascular events in individuals with BMI ≥27 kg/m² without diabetes but with established cardiovascular disease.Good
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
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