Hormonal
Targeting the glucagon receptor (GCGR) with antagonists can promote beta-cell regeneration and improve beta-cell identity in Type 2 Diabetes models.
Research suggests that blocking the glucagon receptor (GCGR) might help regenerate insulin-producing beta cells in people with Type 2 Diabetes. This is a newer area of treatment development, moving beyond just replacing insulin to trying to repair the pancreas itself. While promising in animal studies, this is not yet a standard clinical practice for all patients.
Wei et al. reported that GCGR antagonism promotes β-cell regeneration and that the inhibition of glucagon-GLP-1R signaling reduces the insulin-stimulating effect and β-cell regeneration caused by a GCGR monoclonal antibody in diabetic mice.
Why this rating
Based on mouse models and specific studies cited in a review; clinical translation is still emerging.
Source
Pancreatic Islet Cell Hormones: Secretion, Function, and Diabetes Therapy
Jinfang Ma et al. · MedComm · 2025
DOI 10.1002/mco2.70359
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