Hormonal
GABA signaling can induce the transdifferentiation of alpha cells into beta-like cells, potentially reversing chemically induced diabetes in vivo.
There is experimental evidence that GABA, a neurotransmitter, might help convert alpha cells (which raise blood sugar) into beta-like cells (which lower blood sugar) in diabetic mice. However, the paper also notes that other studies found no such regeneration with long-term GABA or artesunate administration. This remains a research area, not a current treatment option for humans.
Upon sustained GABA exposure, α cells are induced to be converted into β-like cells, which are functional and can repeatedly reverse chemically induced diabetes in vivo.
Why this rating
Based on specific studies in mice with conflicting results regarding long-term efficacy.
Source
Pancreatic Islet Cell Hormones: Secretion, Function, and Diabetes Therapy
Jinfang Ma et al. · MedComm · 2025
DOI 10.1002/mco2.70359
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