Mixed
Combination therapies (e.g., Phentermine/Topiramate, Naltrexone/Bupropion) offer superior weight loss compared to monotherapy by targeting multiple pathways (appetite suppression and calorie absorption/reward), but carry higher risks of adverse effects and require strict monitoring.
Combination drugs like Phentermine/Topiramate can achieve nearly 11% weight loss, significantly better than placebo. They work by suppressing appetite and altering brain signaling. However, they have more side effects (dry mouth, taste disturbance, insomnia) and require careful monitoring for cognitive and cardiovascular effects. They are reserved for patients who need more than single-agent therapy.
The EQUIP study... mean annual weight loss for individuals given the combination therapy was 10.9% (1.6% in the placebo group)... The bupropion/naltrexone combination... weight loss in subjects given the 32/360 mg combination therapy was 6.1%, 6.4%, and 9.3%... (1.3%, 1.2%, and 5.1% on placebo, respectively).
Why this rating
Based on multiple large clinical trials (EQUIP, CONQUER, COR series).
Source
Current pharmacological approaches in obesity treatment
Pelin TİRYAKİOĞLU et al. · DAHUDER Medical Journal · 2023
DOI 10.56016/dahudermj.1271677
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Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
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