Research
Macro partitioning
Omega-3 polyunsaturated fatty acids (PUFAs) and other unsaturated fats inhibit Toll-like receptor 4 (TLR4) activation and pro-inflammatory cytokine release, thereby ameliorating chronic inflammation driven by saturated fats and LPS.
To support a healthy immune response that can resolve inflammation effectively, prioritize unsaturated fats, particularly Omega-3s. These fats actively inhibit inflammatory pathways like TLR4, counteracting the pro-inflammatory effects of saturated fats found in typical Western diets.
GoodSupportsHIGH confidence
On the contrary, omega 3 and PUFAs can interfere with TLR4 activation through inhibition of COX-2 mediated prostaglandin release and thus ameliorate this inflammatory signal (24, 25).
Why this rating
Supported by multiple citations (24, 25, 26, 27, 28, 29) in the review.
Source
You are what you eat: How to best fuel your immune system
Charlotte Hellmich et al. · Frontiers in Immunology · 2022
narrative_reviewCited 2×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →