Energy balance
High intake of dietary fructose (common in Western diets) metabolically rewires innate immunity by increasing mTORC1 activity and IL1B expression in monocytes/macrophages, thereby promoting a pro-inflammatory state and reducing metabolic flexibility.
If you consume a diet high in processed foods containing corn syrup or high-fructose ingredients, you may be inadvertently keeping your immune system in a state of low-grade alert. This happens because fructose pushes immune cells to prioritize inflammatory signaling over metabolic flexibility. Reducing processed fructose intake can help restore normal immune metabolic function.
increased blood levels of fructose present in Western diets (35) metabolically rewire innate immunity. In the recent study monocytes and macrophages exposed to fructose (main component of broadly used corn syrup) have shown increased activity of mTORC1 and expression of IL1B in response to LPS. Furthermore, these cells have reduced metabolic flexibility in response to glycolytic and mitochondrial inhibition, underpinning the pro-inflammatory role of dietary fructose (36).
Why this rating
The paper cites specific recent studies (Ref 36) demonstrating the mechanism in human cells, though it is a review paper summarizing findings rather than primary data itself.
Source
You are what you eat: How to best fuel your immune system
Charlotte Hellmich et al. · Frontiers in Immunology · 2022
DOI 10.3389/fimmu.2022.1003006
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