Research
Mixed
Extreme weight gain (≥20 kg) and substantial weight loss (>2.5 kg) are associated with increased CKD risk, forming a J-shaped or U-shaped relationship.
Avoid both extreme weight gain and substantial weight loss. Even small gains (≥2.5 kg) can increase kidney risk, especially in young adulthood. If you are obese, avoid rapid or substantial weight loss as it may also harm kidney function. Focus on stability.
GoodSupportsHIGH confidence
a J-shaped or U-shaped relationship was observed between CKD risk and absolute weight changes, with both extreme weight gain (≥20 kg) and substantial weight loss (>2.5 kg) associated with increased CKD risk.
Why this rating
Large sample size, but relies on self-reported historical weight data which may introduce recall bias.
Source
Association between weight change across adulthood and risk of chronic kidney disease: NHANES 1999–2020
Xunliang Li et al. · Renal Failure · 2025
DOI 10.1080/0886022x.2024.2448261
cross_sectional · n=34187Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Transitioning from obesity to non-obesity, transitioning from non-obesity to obesity, or maintaining stable obesity is associated with an elevated risk of chronic kidney disease (CKD) compared to maintaining stable non-obesity.Good
- The association between weight change patterns and CKD risk is stronger in individuals under 60 years of age at baseline compared to those 60 years or older.Good
Related findings · Mixed
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