Research
Mixed
The association between weight change patterns and CKD risk is stronger in individuals under 60 years of age at baseline compared to those 60 years or older.
If you are under 60, pay close attention to your weight stability. The risk to your kidneys from weight fluctuations is higher for you than for older adults. Prioritize maintaining a stable, healthy weight.
GoodQualifiesHIGH confidence
Stratified analyses revealed that age and sex played significant roles in these associations, with stronger effects observed among participants under 60 years at baseline.
Why this rating
Large sample size, but stratified analyses reduce power in subgroups.
Source
Association between weight change across adulthood and risk of chronic kidney disease: NHANES 1999–2020
Xunliang Li et al. · Renal Failure · 2025
DOI 10.1080/0886022x.2024.2448261
cross_sectional · n=34187Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Transitioning from obesity to non-obesity, transitioning from non-obesity to obesity, or maintaining stable obesity is associated with an elevated risk of chronic kidney disease (CKD) compared to maintaining stable non-obesity.Good
- Extreme weight gain (≥20 kg) and substantial weight loss (>2.5 kg) are associated with increased CKD risk, forming a J-shaped or U-shaped relationship.Good
Related findings · Mixed
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