Research
Energy balance
At 176 weeks, the mean percent change in body weight among participants who received tirzepatide was -12.3% with the 5-mg dose, -18.7% with the 10-mg dose, and -19.7% with the 15-mg dose, compared with -1.3% among those who received placebo.
Tirzepatide is effective for significant weight loss in individuals with obesity and prediabetes.
StrongSupportsmedium confidence
At 176 weeks, the mean percent change in body weight among the participants who received tirzepatide was -12.3% with the 5-mg dose, -18.7% with the 10-mg dose, and -19.7% with the 15-mg dose, as compared with -1.3% among those who received placebo (P<0.001 for all comparisons with placebo).
Why this rating
Based on a large randomized controlled trial.
Source
Tirzepatide for Obesity Treatment and Diabetes Prevention
Ania M. Jastreboff et al. · New England Journal of Medicine · 2024
DOI 10.1056/nejmoa2410819
rct · n=2539Cited 359×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Fewer participants received a diagnosis of type 2 diabetes in the tirzepatide groups than in the placebo group (1.3% vs. 13.3%).Strong
- Three years of treatment with tirzepatide resulted in substantial and sustained weight reduction and a markedly lower risk of progression to type 2 diabetes than that with placebo.Strong
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