Research
Energy balance
Oral semaglutide at a dose of 25 mg once daily resulted in a mean reduction in body weight of -13.6% from baseline to week 64.
Oral semaglutide may be an effective treatment option for weight loss in adults with obesity.
StrongSupportsmedium confidence
The estimated mean change in body weight from baseline to week 64 was -13.6% in the oral semaglutide group and -2.2% in the placebo group.
Why this rating
Based on a large randomized controlled trial design.
Source
Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity
Sean Wharton et al. · New England Journal of Medicine · 2025
rct · n=307Cited 52×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →