Research
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Participants in the oral semaglutide group were significantly more likely to achieve body-weight reductions of 5% or more, 10% or more, 15% or more, and 20% or more compared to the placebo group.
Oral semaglutide may help patients achieve significant weight loss milestones.
StrongSupportsmedium confidence
Participants in the oral semaglutide group were significantly more likely than those in the placebo group to have body-weight reductions of 5% or more, 10% or more, 15% or more, and 20% or more.
Why this rating
Based on a large randomized controlled trial design.
Source
Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity
Sean Wharton et al. · New England Journal of Medicine · 2025
DOI 10.1056/nejmoa2500969
rct · n=307Cited 52×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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